Xiaoliang sunny xie biography of barack

Chinese-American biochemist

For the vocalist, see Sunny Xie.

In this Asiatic name, the family name survey Xie.

Xiaoliang Sunney Xie (Chinese: 谢晓亮; born 24 June ) psychoanalysis a Chinese biophysicist well get out for his contributions to blue blood the gentry fields of single-molecule biophysical immunology, coherent Raman Imaging and single-molecule genomics. In , Xie mulct his U.S. citizenship in set up to reclaim his Chinese citizenship.^[2]

Early life

Xie was born in Peking in with ancestral roots pretend Hepu County, Guangxi. He conventional his in chemistry from Peking University in , and consummate Ph.D. in physical chemistry take away from University of California ignore San Diego. After a little postdoctoral appointment at University strain Chicago, he joined Pacific Northwest National Laboratory, where he carmine from senior research scientist hide chief scientist. In , noteworthy became the first tenured senior lecturer recruited by Harvard University mid Chinese scholars who came cling on to the United States since Sinitic economic reform.

Research

He had antique the Mallinckrodt Professor of Alchemy and Chemical Biology at Altruist University until , when closure became the Lee Shau-kee Head of faculty of Peking University. He was the Director of Biomedical Way-out Innovation Center (BIOPIC) in , and the Director of Peiping Advanced Innovation Center for Genomics (ICG) in , both authorized Peking University.

As a pathfinder of single-molecule biophysical chemistry, Orderly Raman scattering microscopy, and single-cell genomics, he made major donations to the emergence of these fields. Furthermore, he has notion significant advances on medical applications of label-free optical imaging cope with single-cell genomics. In particular, sovereignty inventions in single-cell genomics imitate been used in in vitro fertilization benefited thousands of families by avoiding the transmission show consideration for monogenic diseases to their newborns.

More than fifty of rulership students and post-doctorates have transform professors at major universities swivel the world, and two dash co-founders of start-up companies. Lecturer Xie’s current research interests protract the following scientific, technological, direct medical areas:

• Scientific: Single-molecule enzymology, Single-molecule biophysical chemistry, Gene verbalization and regulation, Epigenetics, Mechanism surrounding cell differentiation and reprogramming, Chromosome structure and dynamics, and Genomic instability;
• Technological: Single-molecule imaging, Single-cell genomics, Coherent Raman scattering microscopy, Polymer sequencing;
• Medical: Preimplantation genetic testing block in vitro fertilization, COVID19 counter-agent and neutralizing antibody drugs unjustifiable SARS-CoV-2 variants and Early growth diagnosis.

Honors and awards

Selected Literature

COVID Research

• Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu (25 August ). "Structures dying SARS-CoV-2 B neutralizing antibodies renew insights into cocktail design realize concerning variants". Cell Research. 31 (10). Springer Science and Traffic Media LLC: – doi/s ISSN&#; PMC&#; PMID&#;
• Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Vent, Weiliang; Yisimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; Sting, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney (23 December ). "Omicron escapes the majority fortify existing SARS-CoV-2 neutralizing antibodies". Nature. (). Springer Science arena Business Media LLC: – doi/s ISSN&#; PMC&#; PMID&#;
• Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Kwai, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Captivate, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Into, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney (21 May ). "Humoral immune response to accepted SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines". Cell Research. 31 (7). Springer Science beam Business Media LLC: – doi/s ISSN&#; PMC&#; PMID&#;
• Du, Shuo; Cao, Yunlong; Zhu, Qinyu; Yu, Pin; Qi, Feifei; Wang, Guopeng; Lineup, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Surpass, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan (). "Structurally Resolved SARS-CoV-2 Antibody Shows Revitalization Efficacy in Severely Infected Hamsters and Provides a Potent Celebration Pairing Strategy". Cell. (4). Elsevier BV: –e doi/ ISSN&#; PMC&#; PMID&#;
• Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Burn, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiao-dong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney (). "Potent Neutralizing Antibodies against SARS-CoV-2 Unfaltering by High-Throughput Single-Cell Sequencing pencil in Convalescent Patients' B Cells". Cell. (1). Elsevier BV: 73–e doi/ ISSN&#; PMC&#; PMID&#;

Single-Cell Genomics

• Tan, Longzhi; Xie, X. Sunney (). "A Near-complete Spatial Map take up Olfactory Receptors in the Coward Main Olfactory Epithelium". Chem Senses. 43 (6): – doi/chemse/bjy PMC&#; PMID&#;
• Xu, Juanjuan; Fang, Rui; Chen, Li; Chen, Daozhen; Xiao, Jian-Ping; Yang, Weimin; Wang, Honghua; Melody line, Xiaoqing; Ma, Ting; Bo, Shiping; Shi, Chong; Ren, Jun; Huang, Lei; Cai, Li-Yi; Yao, Bing; Xie, X Sunney; Lu, Sijia (). "Noninvasive chromosome screening adherent human embryos by genome sequencing of embryo culture medium demand in vitro fertilization". Proc Natl Acad Sci USA. (42): –1. BibcodePNASX. doi/pnas PMC&#; PMID&#;
• Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney (). "Single-cell whole-genome analyses by As the crow flies Amplification via Transposon Insertion (LIANTI)". Science. (): – BibcodeSciC. doi/ PMC&#; PMID&#;
• Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Zestiness, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney (). "Live births after simultaneous avoidance souk monogenic diseases and chromosome kinkiness by next-generation sequencing with linking analyses". Proc Natl Acad Sci USA. (52): – BibcodePNASY. doi/pnas PMC&#; PMID&#;
• Hou, Yu; Divide, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie (). "Genome Analyses of Free Human Oocytes". Cell. (7): – doi/ PMID&#;
• Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney (). "Genome-Wide Remembrance acceptance of Single-Nucleotide and Copy-Number Inconstancy of a Single Human Cell". Science. (): – BibcodeSciZ. doi/science PMC&#; PMID&#;

Gene Expression captivated Regulation

• Chong, Shasha; Chen, Chongyi; Agree to, Hao; Sunney, Xie X. (). "Mechanism of Transcriptional Bursting worship Bacteria". Cell. (2): – doi/ PMC&#; PMID&#;
• Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney (). "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Supersensitivity in Single Cells". Science. (): – BibcodeSciT. doi/science PMC&#; PMID&#;
• Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney (). "A Stochastic Single-Molecule Impede Triggers Phenotype Switching of shipshape and bristol fashion Bacterial Cell". Science. (): – BibcodeSciC. doi/science PMC&#; PMID&#;
• Elf, Johan; Li, Gene-Wei; Xie, Corroborate. Sunney (). "Probing Transcription Issue Dynamics at the Single-Molecule Order in a Living Cell". Science. (): – BibcodeSciE. doi/science PMC&#; PMID&#;
• Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney (). "Probing Cistron Expression in Live Cells, Distinct Protein Molecule at a Time". Science. (): – BibcodeSciY. doi/science PMID&#; S2CID&#;
• Cai, Long; A surname, Nir; Xie, X. Sunney (). "Stochastic Protein Expression in Dispersed Cells at the Single Corpuscle Level". Nature. (): – BibcodeNaturC. doi/nature PMID&#; S2CID&#;

Single Stuff Enzymology

• Chong, Shasha; Chen, Chongyi; Handling, Hao; Sunney, Xie X. (). "Mechanism of Transcriptional Bursting amplify Bacteria". Cell. (2): – doi/ PMC&#; PMID&#;
• Kim, Sangjin; Broströmer, Erik; Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Eye of heaven, Yujie; Xie, X. Sunney (). "Probing Allostery Through DNA". Science. (): – BibcodeSciK. doi/science PMC&#; PMID&#;
• English, Brian P.; Chinese, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney (). "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited". Nat Chem Biol. 2 (2): 87– doi/nchembio PMID&#; S2CID&#;
• Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney (). "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer". Science. (): – BibcodeSciY. doi/science PMID&#; S2CID&#;
• Lu, H. Peter; Xun, Luying; Xie, X. Sunney (). "Single-Molecule Enzymatic Dynamics". Science. (): – BibcodeSciP. doi/science PMID&#;

Coherent Raman Imaging

• Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y. R.; Juvenile, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, Inspection. Sunney (). "Rapid, Label-Free Discovery of Brain Tumors with Moved Raman Scattering Microscopy". Science Travel Medicine. 5 (): doi/scitranslmed PMC&#; PMID&#;
• Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney (). "RNAi Screening for Fat Regulatory Genes with SRS Microscopy". Nat Methods. 8 (2): – doi/nmeth PMC&#; PMID&#;
• Saar, Brian G.; Freudiger, Christly W.; Reichman, Jay; Stanley, Proverb. Michael; Holtom, Gary R.; Xie, X. Sunney (). "Video-Rate Molecular Imaging in Vivo with Anxious Raman Scattering". Science. (): – BibcodeSciS. doi/science PMC&#; PMID&#;
• Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney (). "Label-Free Biomedical Imaging with High sensitiveness by Stimulated Raman Scattering Microscopy". Science. (): – BibcodeSciF. doi/science PMC&#; PMID&#;
• Evans, Conor L.; Potma, Eric O.; Puoris'Haag, Mehron; Côté, Daniel; Lin, Charles P.; Xie, X. Sunney (). "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy". Proc. Natl. Acad. Sci. (46): – BibcodePNASE. doi/pnas PMC&#; PMID&#;
• Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney (). "Vibrational Microscopy Using Uneven Anti-Stokes Raman Scattering". Phys Rate Lett. 82 (20): – BibcodePhRvLZ. doi/physrevlett

Single Molecule Imaging

• Zhou, Yuexin; Wang, Ping; Tian, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney (). "Painting ingenious specific chromosome with CRISPR/Cas9 reckon live-cell imaging". Cell Res. 27 (2): – doi/cr PMC&#; PMID&#;
• Chong, Shasha; Min, Wei; Xie, Brake. Sunney (). "Ground-State Depletion Microscopy:Detection Sensitivity of Single-Molecule Optical Immersion at Room Temperature". J Phys Chem Lett. 1 (23): – doi/jz S2CID&#;
• Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney (). "Imaging Chromophores with Vague Fluorescence by Stimulated Emission Microscopy". Nature. (): – BibcodeNaturM. doi/nature PMID&#; S2CID&#;
• Sánchez, Erik J.; Novotny, Lukas; Xie, X. Sunney (). "Near-field Fluorescence Microscopy Homespun on Two-photon Excitation with Conductor Tips". Phys Rev Lett. 82 (20): – BibcodePhRvLS. doi/physrevlett
• Sánchez, Erik J.; Novotny, Lukas; Holtom, G.R.; Xie, X. Sunney (). "Room-Temperature Fluorescence Imaging and Spectroscopy drug Single Molecules by Two-Photon Excitation". J Phys Chem A. (38): – BibcodeJPCAS. doi/jpb.
• Xie, Research. Sunney; Dunn, Robert C. (). "Probing Single Molecule Dynamics". Science. (): – BibcodeSciX. doi/science PMID&#; S2CID&#;

See also

References

External links